Currently Recruiting Research Studies


Exercise Collapse Associated with Sickle Cell Trait (ECAST) STUDY

The purpose of this study is to determine who is at greatest risk for Exercise Collapse Associated with Sickle Cell Trait (ECAST) and whether any biomarkers can be applied to risk stratify those susceptible to ECAST. Exercise Collapse Associated with Sickle Cell Trait is defined as a significantly greater than normal effort during exercise, unusual muscle weakness and pain (most commonly in legs and lower back), and normal to modest temperature elevation while initially responsive. To this end, we will: 1) test the effect of deoxygenation on red cell sickling in whole blood from sickle cell trait (SCT) individuals with and without ECAST; 2) test correlations between red blood cell sickling phenotype and genetic variants in SCT individuals with and without ECAST. Findings from this study will guide more evidence-based treatment and policy decisions that impact the ECAST population in both civilian and military sectors.

We are currently enrolling African American, active duty and civilian, men and women (18-45 years old) that have SCT with or without exertional collapse. If you are interested in participating or for more information, please call: (301) 295-1371 or email:



Exertion Related Illness (ERIS) STUDY

The USU Consortium for Health and Military Performance is conducting a study utilizing an interdisciplinary approach to determine molecular subtypes of exertional related illnesses (ERI) and to develop a framework to translate our findings into clinical action. To this end, we: 1) have developed a network within the Military Health System (MHS)  to systematically, efficiently, effectively manage, and triage patients presenting with exertional heat illness and/or exertional rhabdomyolysis (ER); 2) will determine the contributions of intrinsic and extrinsic risk factors associated with ERI, and create a scoring system to triage Service Members to early return to duty or further specialty evaluation for recurrence risk; 3) will develop genetic and biologic screening tools for ERI that can be deployed as far forward as possible with the ultimate goal of differentiating those at risk for recurrence and those who can be returned to full duty. The development of the scoring system for the MHS will allow the treatment provider to learn tests that should be ordered immediately. It will also allow for the treatment provider to inform the patient on the process, how long it might take to be completed, and the potential outcomes.

Please contact the USU Human Performance Lab at (301) 295-1371 if you would like further information regarding how you can participate.